Mayo Clinic Researchers Prove Key Cancer Theory

Posted on December 9th, 2009 by Kelley Luckstein

Mayo Clinic researchers have proven the longstanding theory that changes in the number of whole chromosomes -- called aneuploidy -- can cause cancer by eliminating tumor suppressor genes. Their findings, which appear in the current issue of the journal Cancer Cell along with an independent commentary on the discovery, end a major controversy in the field of cancer research as to whether aneuploidy is a cause or a consequence of cancer…

 

"By using a combination of new and established mouse models for human cancer, we were able to prove that aneuploidy causes cancer and elucidate the mechanism by which it does so," explains Jan van Deursen, Ph.D., Mayo Clinic cancer biologist and senior author.

 

Medical News Today, 12/9/09

Tags: aneuploidy, Cancer, Genomics, tumor supporessor genes

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