August 8, 2012
How Senescent Cells Spur Aging and Cancer
In 1999 JAN M. VAN deursen and his colleagues at the Mayo Clinic in Rochester, Minn., wanted to see whether mangled chromosomes cause cancer. So they engineered mice deficient in a protein that helps to maintain chromosomal integrity. The rodents’ coils of DNA were duly deranged. Surprisingly, though, the animals were not particularly tumor-prone. Instead […]
Tags: chromosomes, DNA, Scientific American, tumors
December 14, 2009
Chromosome changes can cause cancer: U.S. study
A chromosome abnormality called aneuploidy can cause cancer, U.S. researchers said in a study published Monday, confirming what scientists have long suspected. With virtually all human cancers having an abnormal number of chromosomes, scientists have “long suspected that gene mutations which promote erroneous chromosome separation during cell division are to blame for tumor development,” […]
Tags: Cancer, chromosomes, mutations