Cytopia’s CYT387 Receives FDA Clearance to Start US Clinical Trials

By Kelley Luckstein

Cytopia Limited's (ASX: CYT) Investigational New Drug Application (IND) for CYT387 has passed US Food and Drug Administration (FDA) review. CYT387 is a small-molecule oral JAK1/JAK2 kinase inhibitor designed to treat various hematological disorders…

Preparations for the company's initial Phase I/II trial of CYT387 in patients

with myelofibrosis are currently being finalized. Myelofibrosis is a

life-threatening scarring of the bone marrow. This study will be undertaken at

the Mayo Clinic in Rochester Minnesota under the chairmanship of Dr. Ayalew

Tefferi, a key opinion leader in MPD treatment. The company anticipates

opening the study to enrolment in the fourth quarter of 2009. Further details

of the study will be disclosed following site ethics committee approval.

Reuters, 09/03/09