E! has released a statement to The Hollywood Reporter regarding Giuliana Rancic's decision to undergo a double mastectomy, saying that "we admire her courage and are proud to stand by her side through every step on her path to full recovery."… if you have more than one tumor in different areas in the breast, or if you have an extremely large tumor that doesn't leave behind much healthy tissue, among other reasons, according to the Mayo Clinic.
Huffington Post, 12/5/11
Additional coverage: Z6Mag