June 22, 2018

UNF, Mayo experiment with rare 3-D microscope

By Karl Oestreich

Jacksonville Business Journal
by Will Robinson

Materials Science and Engineering Research Facility watched as dozens of dots scattered across their computer screen. Some dots balled up, others exploded. The dots were cancerous cells from a brain tumor recently removed by a Mayo Clinic neurosurgeon. The visual was made possible by an advanced microscope, the only one of its kind in North America, which can zoom into individual cells without staining and killing cells, as microscopes typically do. "It gives a great view of cells interacting," said Maarten Rotman, a post-doctoral researcher in the Mayo Neurosurgery Lab.

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Additional coverage:
Florida Times-Union, High-powered microscope on loan to UNF proves to be excellent research tool by Charlie Patton — Maarten Rotman and Anna Carrano, post-doctoral fellows with the Mayo Clinic in Jacksonville, have been using the microscope to study the behavior of Glioblastoma cells, a type of cancer that can occur in the brain or spinal cord. The cancer is very aggressive, very difficult to treat and for which no cure has been found. “We want to know why certain brain cancer cells spread out over the brain and resist chemotherapeutic treatment and what we can do to stop that,” said Rotman, who works as a researcher in the Mayo Neurosurgery Lab of Alfredo Quinones-Hinojosa. “Using the Q-Phase microscope, we’re analyzing with great clarity the effects of certain new treatments on the mobility and survival of brain cancer cells.”

Context:  Maarten Rotman, Ph.D.  is a post-doctoral researcher in The Brain Tumor Stem Cell Research Laboratory of Alfredo Quinones-Hinojosa, M.D. The lab focuses on elucidating molecular and cellular pathways involved in the progression of tumors arising in the central nervous system, in particular glioblastoma. In collaboration with partners across multiple Mayo Clinic departments and other research institutions, the laboratory team designs novel therapeutic agents and explores the potential for translation into human clinical trials. Dr. Rotman's research is focused on using the human fat (adipose) tissue-derived mesenchymal stem cell to battle brain tumor initiating cells.

Contact:  Kevin Punsky


Tags: Dr. Alfredo Quinones-Hinojosa, Dr. Maarten Rotman, neurosurgery, Uncategorized

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