August 8, 2012
How Senescent Cells Spur Aging and Cancer
In 1999 JAN M. VAN deursen and his colleagues at the Mayo Clinic in Rochester, Minn., wanted to see whether mangled chromosomes cause cancer. So they engineered mice deficient in a protein that helps to maintain chromosomal integrity. The rodents’ coils of DNA were duly deranged. Surprisingly, though, the animals were not particularly tumor-prone. Instead […]
Tags: chromosomes, DNA, Scientific American, tumors