Items Tagged ‘T cell exhaustion’

May 10, 2012

Mayo Clinic: Exhaustion Renders Immune Cells Less Effective in Cancer Treatment


Rather than stimulating immune cells to more effectively battle cancerous tumors, treatment with the protein interleukin-12 (IL-12) has the opposite effect, driving these intracellular fighters to exhaustion, a Mayo Clinic study has found. The findings appear in the Journal of Clinical Investigation.The study helps explain the negative results of clinical trials testing the treatment’s ability […]

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Tags: cancerous tumors, immune cells, Journal of Clinical Investigation, Science Newsline, T cell exhaustion

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